February 20, 2012
This February, a group from Michigan presented a synthesized view on statin use in the preoperative period. The authors reviewed 15 prospective randomized controlled studies of statin initiation. Reported clinical outcomes included atrial fibrillation, myocardial infarction, length of stay and death.
In this meta-analysis myocardial infarction and length of stay were noted to be significantly reduced among patients initiated on statins. There was a non-significant trend toward reduced mortality as well. Notably, atrial fibrillation was also reduced among the cardiac surgery subset with a number needed to treat of only 6.
The authors suggest that broader use of statins in the preoperative period be considered; thought consensus data is lacking on the best timing or dosing.